产品
编 号：F753948
分子式：C21H15F4N5O3S
分子量：493.43
分子式：C21H15F4N5O3S
分子量：493.43
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CAS No: 2586195-28-8
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生物活性：
Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer.
体外研究：
Androgen receptor antagonist 5 has antiproliferative activity against LNCaP with an IC50 of 14.8 ± 0.57 μM.
Androgen receptor antagonist 5 (compound 42f) is a potent androgen receptor (AR) antagonist with an IC50 value of 6.17 μM. Androgen receptor antagonist 5 can effectively impair AR nuclear translocation, reducing the levels of nuclear AR, and disrupts AR-mediated gene regulation. Androgen receptor antagonist 5 has antiproliferative activity against LNCaP and exhibits antitumor activity in LNCaP xenograft tumor mice model. Androgen receptor antagonist 5 can be used for researching prostate cancer.
体外研究：
Androgen receptor antagonist 5 has antiproliferative activity against LNCaP with an IC50 of 14.8 ± 0.57 μM.
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