产品
编 号：F753940
分子式：C46H41N7O8
分子量：819.86
分子式：C46H41N7O8
分子量：819.86
产品类型
规格
价格
是否有货
结构图
CAS No: 2585561-36-8
产品详情
生物活性：
PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 Degrader, with IC50 values of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-16 ignificantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-16 significantly induces apoptosis in MV-4-11 cells.
体外研究：
PROTAC BRD4 Degrader-16 (compound 7f) (100 nM, 4-24 h) 在 MV-4-11 细胞中以 100 nM 浓度在 4 h 显著诱导 BRD4 L 和 BRD4 S 降解，然后在 24 h 像 dBET6 (HY-112588) 一样恢复 BRD4 S。
PROTAC BRD4 Degrader-16 is a potent PROTAC BRD4 Degrader, with IC50 values of 34.58 nM (BRD4 (BD1)) and 40.23 nM (BRD4 (BD2)). PROTAC BRD4 Degrader-16 ignificantly attenuates G2/M progression associated Cyclin B1 expression. PROTAC BRD4 Degrader-16 significantly induces apoptosis in MV-4-11 cells.
体外研究：
PROTAC BRD4 Degrader-16 (compound 7f) (100 nM, 4-24 h) 在 MV-4-11 细胞中以 100 nM 浓度在 4 h 显著诱导 BRD4 L 和 BRD4 S 降解，然后在 24 h 像 dBET6 (HY-112588) 一样恢复 BRD4 S。
产品资料
Copyright©2015-2024 沪ICP备2022026524号-1
沪公网安备