产品
编 号：F753934
分子式：C10H11ClF3NO2S
分子量：301.71
分子式：C10H11ClF3NO2S
分子量：301.71
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2584947-79-3
产品详情
生物活性：
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.
体内研究：
PXS-6302 hydrochloride 在猪切除和烧伤模型中抑制 LOX、减少交联并改善疤痕外观。PXS-6302 hydrochloride (1.5%，水包油乳膏；500 mg 乳膏涂于 16 cm2；外用；每天一次，持续 28 天) 减少小鼠损伤模型中的胶原蛋白沉积和交联蛋白 局部应用下的纤维化。PXS-6302 hydrochloride (0.5、1.5 或 3%，水包油霜；400 mg 霜，涂于 16 cm2；外用；每日一次，持续 12 周) 也可显着改善疤痕外观，且不会减少疤痕局部应用下猪损伤模型的组织强度。Animal Model:Porcine excision injury model (female Juvenile pigs, 18-20 kg).
Dosage:0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2
Administration:External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks
Result:Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance.Molecular Weight265.25FormulaC10H10F3NO2SCAS No.2584947-54-4SMILESNC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\FShippingRoom temperature in continental US; may vary elsewhere.StoragePlease store the product under the recommended conditions in the Certificate of Analysis.Purity & DocumentationData Sheet (270 KB)Handling Instructions (2659 KB)References. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. [Content Brief]
体外研究：
PXS-6302 hydrochloride 对单层细胞 (例如 Caco-2 或 MDCKII 细胞) 具有高渗透性。
PXS-6302 hydrochloride is an irreversible lysyl oxidase inhibitor with IC50s of 3.7 μM (Bovine LOX), 3.4 μM (rh LOXL1), 0.4 μM (rh LOXL2), 1.5 μM (rh LOXL3), 0.3 μM (rh LOXL4), respectively. PXS-6302 hydrochloride has readily skin penetrability, reduces collagen deposition and significantly improves scar appearance.
体内研究：
PXS-6302 hydrochloride 在猪切除和烧伤模型中抑制 LOX、减少交联并改善疤痕外观。PXS-6302 hydrochloride (1.5%，水包油乳膏；500 mg 乳膏涂于 16 cm2；外用；每天一次，持续 28 天) 减少小鼠损伤模型中的胶原蛋白沉积和交联蛋白 局部应用下的纤维化。PXS-6302 hydrochloride (0.5、1.5 或 3%，水包油霜；400 mg 霜，涂于 16 cm2；外用；每日一次，持续 12 周) 也可显着改善疤痕外观，且不会减少疤痕局部应用下猪损伤模型的组织强度。Animal Model:Porcine excision injury model (female Juvenile pigs, 18-20 kg).
Dosage:0.5, 1.5, or 3%, oil in water cream; 400 mg cream applied to 16 cm2
Administration:External application; 1, 2 and 3 weeks post-injury; once dayly, for 12 weeks
Result:Showed significantly higher scores for the 3% treated scars suggesting significant improvement in scar appearance.Molecular Weight265.25FormulaC10H10F3NO2SCAS No.2584947-54-4SMILESNC/C=C(C(F)(S(=O)(C1=CC=CC=C1)=O)F)\FShippingRoom temperature in continental US; may vary elsewhere.StoragePlease store the product under the recommended conditions in the Certificate of Analysis.Purity & DocumentationData Sheet (270 KB)Handling Instructions (2659 KB)References. Chaudhari N, et al. Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis. Nat Commun. 2022 Sep 22;13(1):5555. [Content Brief]
体外研究：
PXS-6302 hydrochloride 对单层细胞 (例如 Caco-2 或 MDCKII 细胞) 具有高渗透性。
产品资料
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