产品
编 号：F753912
分子式：C27H20IN3O4
分子量：577.37
分子式：C27H20IN3O4
分子量：577.37
产品类型
规格
价格
是否有货
结构图
CAS No: 2581824-80-6
产品详情
生物活性：
MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers.
体外研究：
MMP-9-IN-5 (compound 8, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells.MMP-9-IN-5 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively.MMP-9-IN-5 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively .MMP-9-IN-5 (3.1 nM, 24 h) inhibits cell migration in HepG-2 cells.
MMP-9-IN-5 is a MMP-9 inhibitor (IC50: 4.49 nM) that forms hydrogen bond with MMP-9. MMP-9-IN-5 also inhibits AKT activity (IC50: 1.34 nM). MMP-9-IN-5 shows cell cytotoxicity and induces cell apoptosis. MMP-9-IN-5 can be used in the research of cancers.
体外研究：
MMP-9-IN-5 (compound 8, 0-1 μM approximately, 72 h) shows cytotoxicity to Wi-38, MCF-7, NFS-60, HepG-2 cells.MMP-9-IN-5 (72 h) induces apoptosis in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively.MMP-9-IN-5 (72 h) induces significant caspase 3/7 activation in MCF-7, NFS-60 and HepG-2 cells at 6.9 nM, 5.5 nM, 3.1 nM respectively .MMP-9-IN-5 (3.1 nM, 24 h) inhibits cell migration in HepG-2 cells.
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