产品
编 号：F753909
分子式：C67H99N13O18S3
分子量：1470.77
分子式：C67H99N13O18S3
分子量：1470.77
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 2581741-18-4
产品详情
生物活性：
FAP-2286 is a potent and selective FAP-binding peptide coupled to a radionuclide chelator with a mean IC50 value of 2.7 nM for binding to FAP. FAP-2286 can chelate radionuclides for imaging or therapeutic applications and has a strong effect on FAP-positive tumors. FAP-2286 can be used for FAP-positive tumor research.
体内研究：
FAP-2286 (30 MBq/nmol，静脉注射) 在 HEK-FAP 肿瘤移植小鼠模型中稳定积累。Animal Model:HEK-FAP tumor-bearing mice
Dosage:30 MBq/nmol
Administration:Intravenous injection (i.v.)
Result:Increased tumor-to-kidney (T/K) ratio with the highest differential uptake of 7.5 T/K obtained at 48 h post injection.Maintained accumulation at 3 h after injection with 10.8 ID/g.
体外研究：
FAP-2286 (0.1-30 nM, 1小时) 减少与人 WI-38 成纤维细胞样胎儿肺细胞系结合的荧光团标记的竞争肽。FAP-2286 (5 nM, 1, 3, 8, 24, 和72小时) 在 HEK-FAP 细胞中维持长时间的肿瘤保留和抑制。
FAP-2286 is a potent and selective FAP-binding peptide coupled to a radionuclide chelator with a mean IC50 value of 2.7 nM for binding to FAP. FAP-2286 can chelate radionuclides for imaging or therapeutic applications and has a strong effect on FAP-positive tumors. FAP-2286 can be used for FAP-positive tumor research.
体内研究：
FAP-2286 (30 MBq/nmol，静脉注射) 在 HEK-FAP 肿瘤移植小鼠模型中稳定积累。Animal Model:HEK-FAP tumor-bearing mice
Dosage:30 MBq/nmol
Administration:Intravenous injection (i.v.)
Result:Increased tumor-to-kidney (T/K) ratio with the highest differential uptake of 7.5 T/K obtained at 48 h post injection.Maintained accumulation at 3 h after injection with 10.8 ID/g.
体外研究：
FAP-2286 (0.1-30 nM, 1小时) 减少与人 WI-38 成纤维细胞样胎儿肺细胞系结合的荧光团标记的竞争肽。FAP-2286 (5 nM, 1, 3, 8, 24, 和72小时) 在 HEK-FAP 细胞中维持长时间的肿瘤保留和抑制。
产品资料
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