产品
编 号：F753857
分子式：C24H31BrN8O
分子量：527.46
分子式：C24H31BrN8O
分子量：527.46
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2574474-81-8
产品详情
生物活性：
TP-5801 is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor (IC50=1.40 nM), and shows anti-tumor activity.
体内研究：
TP-5801 (oral gavage; 10 mg/kg; once) treatment shows efficacy in the mouse survival model.TP-5801 (oral gavage; 50 mg/kg; once daily; 7 d) treatment can inhibit localized tumor growth.Animal Model:Female NOD/SCID mice injected with Ba/F3 luc cells expressing TNK1 AAA
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg; once
Result:Showed no signs of toxicity and significantly prolonged lifespan.
Animal Model:NOD/SCID mice implanted subcutaneously with Ba/F3 luc cells expressing TNK1 AAA or BCR-ABL
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg; once daily; 7 days
Result:Reduced phospho-STAT3 in TNK1-driven xenografts at 2?hours post-treatment, and tumor burden in mice xenografted.
体外研究：
TP-5801 (10?pM-10?μM; 72 h) treatment inhibits TNK1-driven, BCR-ABL-driven and IL-3-driven Ba/F3 cell growth.TP-5801 (1?nM-10?μM; 10 d) inhibits TNK1-dependent L540 cell growth.
TP-5801 is an orally active TNK1 (non-receptor tyrosine kinase) inhibitor (IC50=1.40 nM), and shows anti-tumor activity.
体内研究：
TP-5801 (oral gavage; 10 mg/kg; once) treatment shows efficacy in the mouse survival model.TP-5801 (oral gavage; 50 mg/kg; once daily; 7 d) treatment can inhibit localized tumor growth.Animal Model:Female NOD/SCID mice injected with Ba/F3 luc cells expressing TNK1 AAA
Dosage:10 mg/kg
Administration:Oral gavage; 10 mg/kg; once
Result:Showed no signs of toxicity and significantly prolonged lifespan.
Animal Model:NOD/SCID mice implanted subcutaneously with Ba/F3 luc cells expressing TNK1 AAA or BCR-ABL
Dosage:50 mg/kg
Administration:Oral gavage; 50 mg/kg; once daily; 7 days
Result:Reduced phospho-STAT3 in TNK1-driven xenografts at 2?hours post-treatment, and tumor burden in mice xenografted.
体外研究：
TP-5801 (10?pM-10?μM; 72 h) treatment inhibits TNK1-driven, BCR-ABL-driven and IL-3-driven Ba/F3 cell growth.TP-5801 (1?nM-10?μM; 10 d) inhibits TNK1-dependent L540 cell growth.
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