产品
编 号：F753816
分子式：C26H40N2O3
分子量：428.61
分子式：C26H40N2O3
分子量：428.61
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 256955-84-7
产品详情
生物活性：
Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects.
体外研究：
In mice,Co 134444(0.5-10 mg/kg,IP,15 min;1-60 mg/kg, PO; 30 min) demonstrates efficacy against pentylenetetrazol (PTZ)-induced seizures with an ED50 of 3.3 mg/kg afterIPadministrationand9.8 mg/kgorally. Similarly, protection against maximal electroshock (MES) is observed with an ED50 of 4.8 mg/kg IP and 20.6 mg/kg PO. In rats, Co134444 (10-40 mg/kg; PO; 30 min) protects against PTZ-induced seizures and MES-induced seizures with an ED50 of 23.6 mg/kg and 25.3 mg/kg, respectively.
Posovolone (Co 134444) is an orally active, neuroactive steroid. Posovolone has anticonvulsant and anxiolytic-like activity as well as ataxic effects.
体外研究：
In mice,Co 134444(0.5-10 mg/kg,IP,15 min;1-60 mg/kg, PO; 30 min) demonstrates efficacy against pentylenetetrazol (PTZ)-induced seizures with an ED50 of 3.3 mg/kg afterIPadministrationand9.8 mg/kgorally. Similarly, protection against maximal electroshock (MES) is observed with an ED50 of 4.8 mg/kg IP and 20.6 mg/kg PO. In rats, Co134444 (10-40 mg/kg; PO; 30 min) protects against PTZ-induced seizures and MES-induced seizures with an ED50 of 23.6 mg/kg and 25.3 mg/kg, respectively.
产品资料
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