产品
编 号：F753762
分子式：C25H21ClF2N6O6S
分子量：606.99
分子式：C25H21ClF2N6O6S
分子量：606.99
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CAS No: 2565705-01-1
产品详情
生物活性：
Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM.
体内研究：
Dot1L-IN-6 (Compound 9) shows an excellent blood exposure after a single dose (100 mg/kg).
体外研究：
Dot1L-IN-6 (Compound 9) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=12 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=170 nM).
Dot1L-IN-6 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.19 nM.
体内研究：
Dot1L-IN-6 (Compound 9) shows an excellent blood exposure after a single dose (100 mg/kg).
体外研究：
Dot1L-IN-6 (Compound 9) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=12 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=170 nM).
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