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编 号：F753705
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1mg
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CAS No: 2559704-24-2
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生物活性：
Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer.
体内研究：
Izalontamab (5-46 mg/kg；静脉注射，每 7 天 1 次，共 4 次) 对不同类型肿瘤显示不同的抗肿瘤疗效。Animal Model:Female NOD/SCID mouse with SW48, FaDu and KYSE-150 xenografts
Dosage:10, 25 and 46 mg/kg (SW48); 5, 10 and 25 mg/kg (FaDu and KYSE-150)
Administration:Intravenous injection;10, 25 and 46 mg/kg (SW48); 5, 10 and 25 mg/kg (FaDu and KYSE-150); every 7 days once, 4 doses in total
Result:Dose-dependently inhibited the growth of FaDu and KYSE-150 tumors at the dose of 10 mg/kg. Inhibited 63.6% SW48 tumor growth at the dose of 46 mg/kg.
Izalontamab (SI-B001) is a bispecific anti-EGFR/HER3 monoclonal antibody with high selectivity for EGFR/HER3 heterodimer. Izalontamab can be used for the research of cancer.
体内研究：
Izalontamab (5-46 mg/kg；静脉注射，每 7 天 1 次，共 4 次) 对不同类型肿瘤显示不同的抗肿瘤疗效。Animal Model:Female NOD/SCID mouse with SW48, FaDu and KYSE-150 xenografts
Dosage:10, 25 and 46 mg/kg (SW48); 5, 10 and 25 mg/kg (FaDu and KYSE-150)
Administration:Intravenous injection;10, 25 and 46 mg/kg (SW48); 5, 10 and 25 mg/kg (FaDu and KYSE-150); every 7 days once, 4 doses in total
Result:Dose-dependently inhibited the growth of FaDu and KYSE-150 tumors at the dose of 10 mg/kg. Inhibited 63.6% SW48 tumor growth at the dose of 46 mg/kg.
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