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编 号：F753678
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CAS No: 2550869-33-3
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生物活性：
Lomtegovimab (BI 767551) is a human anti-SARS-COV-2 spike glycoprotein monoclonal antibody. Lomtegovimab binds and neutralizes SARS-CoV-2. Lomtegovimab shows antiviral efficacy. Lomtegovimab has the potential for the research of COVID-19.
体内研究：
Lomtegovimab (40 mg/kg；i.p. 或 i.n.；一次；感染前三天) 保护 hACE2 转导的小鼠免受 SARS-CoV-2 感染。Animal Model:BALB/c mice (Ad_ACE2-mCherry)
Dosage:40 mg/kg
Administration:I.p. or I.n.; once; three days before infection
Result:Led to a complete neutralization of infectious SARS-CoV-2 and slightly reduced amounts of viral RNA in the lungs of treated animals.
体外研究：
Lomtegovimab 靶向 SARS-CoV-2 S 的 RBD，KD 值为 1.09 nM。Lomtegovimab 显示中和活性，对 SARS-CoV-2 S D614G, SARS-CoV-2 S B.1.1.7, SARS-CoV-2 BavPat1 (B.1) 的 IC50 值分别为 0.001、0.001、0.010 μg/mL。
Lomtegovimab (BI 767551) is a human anti-SARS-COV-2 spike glycoprotein monoclonal antibody. Lomtegovimab binds and neutralizes SARS-CoV-2. Lomtegovimab shows antiviral efficacy. Lomtegovimab has the potential for the research of COVID-19.
体内研究：
Lomtegovimab (40 mg/kg；i.p. 或 i.n.；一次；感染前三天) 保护 hACE2 转导的小鼠免受 SARS-CoV-2 感染。Animal Model:BALB/c mice (Ad_ACE2-mCherry)
Dosage:40 mg/kg
Administration:I.p. or I.n.; once; three days before infection
Result:Led to a complete neutralization of infectious SARS-CoV-2 and slightly reduced amounts of viral RNA in the lungs of treated animals.
体外研究：
Lomtegovimab 靶向 SARS-CoV-2 S 的 RBD，KD 值为 1.09 nM。Lomtegovimab 显示中和活性，对 SARS-CoV-2 S D614G, SARS-CoV-2 S B.1.1.7, SARS-CoV-2 BavPat1 (B.1) 的 IC50 值分别为 0.001、0.001、0.010 μg/mL。
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