产品
编 号：F753634
分子式：C19H27ClF2N2O2
分子量：388.88
分子式：C19H27ClF2N2O2
分子量：388.88
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
25mg
询价
询价
结构图
CAS No: 2535970-65-9
产品详情
生物活性：
EST73502 monohydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 monohydrochloride has antinociceptive activity.
体内研究：
EST73502 monohydrochloride (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test in CD1 male mice.EST73502 monohydrochloride (5 mg/kg; i.p.; twice a day; for 10 days) attenuates partial sciatic nerve ligation (PSNL)-induced mechanical allodynia in male CD1 mice.Animal Model:Male CD1 mice, PSNL model
Dosage:5 mg/kg
Administration:Intraperitoneal injection, twice a day, for 10 days
Result:Attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%.
EST73502 monohydrochloride is a selective, orally active and blood-brain barrier (BBB) penetrant dual μ-opioid receptor (MOR) agonist and σ1 receptor (σ1R) antagonist, with Kis of 64 nM and 118 nM for MOR and σ1R, respectively. EST73502 monohydrochloride has antinociceptive activity.
体内研究：
EST73502 monohydrochloride (10-40 mg/kg; p.o.) shows a dose-response analgesic effect reaching a maximum of 64% and an EC50 of 14 mg/kg in the paw pressure test in CD1 male mice.EST73502 monohydrochloride (5 mg/kg; i.p.; twice a day; for 10 days) attenuates partial sciatic nerve ligation (PSNL)-induced mechanical allodynia in male CD1 mice.Animal Model:Male CD1 mice, PSNL model
Dosage:5 mg/kg
Administration:Intraperitoneal injection, twice a day, for 10 days
Result:Attenuated the expression of mechanical allodynia induced by PSNL, reaching a maximal effect of 56%.
产品资料
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