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编 号:F753612
分子式:C11H9ClFN3O2
分子量:269.66
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生物活性:
COX-2-IN-20 (Compound 5d) is a selective and orally active COX-2 inhibitor with an IC50 of 17.9 nM. COX-2-IN-20 shows anti-inflammatory activity.

体内研究:
COX-2-IN-20 (Compound 5d) (5 mg/kg) exhibits better in vivo anti-inflammation and gastric protection than 10 mg/kg Indomethacin.

体外研究:
COX-2-IN-20 (Compound 5d) shows potential anti-inflammatory activity on NO inhibition in LPS-induced RAW 264.7 cell with an IC50 of 2.87 μM.
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