产品
编 号：F753509
分子式：C34H29NO7
分子量：563.6
分子式：C34H29NO7
分子量：563.6
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CAS No: 2512847-37-7
产品详情
生物活性：
SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC50 value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection.
体内研究：
SAP2-IN-1 (compound 24a) (i.p.; 10 mg/kg; once daily; for four days) shows potent in vivo efficacy in a murine model of invasive candidiasis.Animal Model:a murine model of invasive candidiasis
Dosage:10 mg/kg
Administration:intraperitoneally administration, once daily, for four days
Result:Significantly reduced the fungal burden in the kidney.
体外研究：
SAP2-IN-1 (compound 24a) (100 μM) shows potent SAP2 inhibitory activity with an IC50 value of 0.92 μM.SAP2-IN-1 (100 μM) has not inhibit the growth of C. albicans and inactive in vitro.SAP2-IN-1 (64 μg/mL) blocks fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1.
SAP2-IN-1 is a secreted aspartic protease 2 (SAP2) inhibitor and has potent SAP2 inhibitory activity with an IC50 value of 0.92 μM. SAP2-IN-1 also is a virulence factor inhibitor and is inactive in vitro. SAP2-IN-1 can be used for the research of infection.
体内研究：
SAP2-IN-1 (compound 24a) (i.p.; 10 mg/kg; once daily; for four days) shows potent in vivo efficacy in a murine model of invasive candidiasis.Animal Model:a murine model of invasive candidiasis
Dosage:10 mg/kg
Administration:intraperitoneally administration, once daily, for four days
Result:Significantly reduced the fungal burden in the kidney.
体外研究：
SAP2-IN-1 (compound 24a) (100 μM) shows potent SAP2 inhibitory activity with an IC50 value of 0.92 μM.SAP2-IN-1 (100 μM) has not inhibit the growth of C. albicans and inactive in vitro.SAP2-IN-1 (64 μg/mL) blocks fungi biofilm and hypha formation by down-regulating the expression of genes SAP2, ECE1, ALS3 and EFG1.
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