产品
编 号：F753412
分子式：C17H13NO5
分子量：311.29
分子式：C17H13NO5
分子量：311.29
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CAS No: 2499491-04-0
产品详情
生物活性：
STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 μM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis.
体内研究：
STAT3-IN-10 (A11) (i.p.; 5, 10 mg/kg; once a day, 21 days) inhibits the growth of human xenograft tumor in vivo.Animal Model:Five weeks old female BALB/c nude mice (16–18g) bearing inoculation of human breast cancer cells MDA-MB-231.
Dosage:5 and 10 mg/kg
Administration:IP, once a day, 21 days
Result:Inhibited the growth of human xenograft tumor in vivo without apparent body-weight loss for treated mice and inhibited the levels of p-STAT3 in tumor tissues.
体外研究：
STAT3-IN-10 (A11) (48 h) shows IC50 values of 0.67, 0.77, 1.24 μM against MDA-MB-231, MDA-MB-468, HepG2 cells, respectively.STAT3-IN-10 (A11) directly binds to the STAT3 SH2 domain .STAT3-IN-10 (A11) (0-3 μM, 24 h) inhibits the phosphorylation of STAT3 and its downstream target proteins and has a good selectivity against the tumor suppressor STAT1 .STAT3-IN-10 (A11) (0-4 μM, 24 h) induces apoptosis in cancer cells.STAT3-IN-10 (A11) (0-4 μM, 24 h) dose-dependently causes a significant S phase arrest in MDA-MB-231 cells.
STAT3-IN-10 is a STAT3 inhibitor with an IC50 value of 5.18 μM. STAT3-IN-10 directly binds to STAT3 SH2 domain, induces cancer cells apoptosis.
体内研究：
STAT3-IN-10 (A11) (i.p.; 5, 10 mg/kg; once a day, 21 days) inhibits the growth of human xenograft tumor in vivo.Animal Model:Five weeks old female BALB/c nude mice (16–18g) bearing inoculation of human breast cancer cells MDA-MB-231.
Dosage:5 and 10 mg/kg
Administration:IP, once a day, 21 days
Result:Inhibited the growth of human xenograft tumor in vivo without apparent body-weight loss for treated mice and inhibited the levels of p-STAT3 in tumor tissues.
体外研究：
STAT3-IN-10 (A11) (48 h) shows IC50 values of 0.67, 0.77, 1.24 μM against MDA-MB-231, MDA-MB-468, HepG2 cells, respectively.STAT3-IN-10 (A11) directly binds to the STAT3 SH2 domain .STAT3-IN-10 (A11) (0-3 μM, 24 h) inhibits the phosphorylation of STAT3 and its downstream target proteins and has a good selectivity against the tumor suppressor STAT1 .STAT3-IN-10 (A11) (0-4 μM, 24 h) induces apoptosis in cancer cells.STAT3-IN-10 (A11) (0-4 μM, 24 h) dose-dependently causes a significant S phase arrest in MDA-MB-231 cells.
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