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编 号：F753394
分子式：C59H62N9O13P
分子量：1136.15
分子式：C59H62N9O13P
分子量：1136.15
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CAS No: 2497583-03-4
产品详情
生物活性：
STAT3 degrader-2 is a PROTAC-based degrader of STAT3. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases. STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
STAT3 degrader-2 (Compound 92) (i.v.; 50 mg/kg; 6 h, 24 h, 48 h) 降低急性白血病 Molm-16 肿瘤和 SU-DHL-1 中总 STAT3 蛋白和磷酸化 STAT3 (Y705) 蛋白的水平小鼠肿瘤。STAT3 degrader-2 (i.v.; 25, 50 mg/kg; qw) 对小鼠的 Molm-16 异种移植肿瘤显示出抗肿瘤活性。Animal Model:Mice
Dosage:25, 50 mg/kg
Administration:i.v.; qw
Result:Showed antitumor activity in Molm-16 and SU-DHL-1 xenograft mice.
体外研究：
STAT3 degrader-2 (Compound 92) (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM; 3 h) 降低急性白血病 Molm-16 细胞中的总 STAT3 蛋白水平。
STAT3 degrader-2 is a PROTAC-based degrader of STAT3. STAT3 degrader-2 can degrade the level of total STAT3 protein. STAT3 degrader-2 can be used for the research of cancer and other diseases. STAT3 degrader-2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
体内研究：
STAT3 degrader-2 (Compound 92) (i.v.; 50 mg/kg; 6 h, 24 h, 48 h) 降低急性白血病 Molm-16 肿瘤和 SU-DHL-1 中总 STAT3 蛋白和磷酸化 STAT3 (Y705) 蛋白的水平小鼠肿瘤。STAT3 degrader-2 (i.v.; 25, 50 mg/kg; qw) 对小鼠的 Molm-16 异种移植肿瘤显示出抗肿瘤活性。Animal Model:Mice
Dosage:25, 50 mg/kg
Administration:i.v.; qw
Result:Showed antitumor activity in Molm-16 and SU-DHL-1 xenograft mice.
体外研究：
STAT3 degrader-2 (Compound 92) (0.2 μM, 1 μM, 30 nM, 100 nM, 300 nM; 3 h) 降低急性白血病 Molm-16 细胞中的总 STAT3 蛋白水平。
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