产品
编 号:F753349
分子式:C23H22N8O4S
分子量:506.54
产品类型
结构图
CAS No: 2492376-85-7
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产品详情
生物活性:
PI3K/mTOR Inhibitor-8 (Compound 18b) is a PI3K and mTOR dual inhibitor with IC50 values of 0.46 nM and 12 nM against PI3Kα and mTOR, respectively. PI3K/mTOR Inhibitor-8 induces HCT-116 cells apoptosis and arrests cell cycle at the G1/S phase.
体外研究:
PI3K/mTOR Inhibitor-8 (Compound 18b) shows anti-proliferation activities with IC50 values of 1.95 ± 0.02, 2.02 ± 0.01, 1.62 ± 0.01 and 1.55 ± 0.01 μM against PC-3, HCT-116, A549 and MDA-MB-231 cells, respectively.