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编 号:F753330
分子式:C23H16N2O2S
分子量:384.45
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生物活性:
FTase-IN-1 (compound 17a) is a potent and specific inhibitor of fanesyl transferase (FTase) with an IC50 of 0.35 μM. FTase-IN-1 displays cytotoxicity potential and antitumor activity.

体外研究:
FTase-IN-1 (compound 17a) (10 μM, 48 h) is an inhibitors of farnesyl transferase (FTase) and inhibits NCI-60 cells proliferation in vitro.FTase-IN-1 (10 μM, 48 h) arrests the cell growth of multiple cancer cell lines with GI50 range from 1.8 to 6.5 nM.
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