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编 号：F753264
分子式：C30H32N2O4Se
分子量：563.55
分子式：C30H32N2O4Se
分子量：563.55
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CAS No: 2487457-15-6
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生物活性：
Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma.
体外研究：
Anticancer agent 50 (compound 6) (0-100 μM) shows cytotoxic effects with IC50s of 0.67, 0.90 μM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively.Anticancer agent 50 (0-100 μM) shows antiproliferative effects with IC50s of 3.84, 1.34 μM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively.Anticancer agent 50 (0.1, 0.5, 2 μM; 24 h) inhibits cell cycle progression through the reduction of the expression of cyclin D1 and inhibits cell proliferation by inducing p53 expression.Anticancer agent 50 (0.1, 0.5, 2, 10 μM; 72 h) inhibits cell growth by 12% in SH-SY5Y cells.
Anticancer agent 50 (compound 6) is a potent ABCB1 efflux pump modulator. Anticancer agent 50 shows cytotoxic effects and antiproliferative effects. Anticancer agent 50 decreases the expression of cyclin D1 and induces p53 expression. Anticancer agent 50 has the potential for the research of T-lymphoma.
体外研究：
Anticancer agent 50 (compound 6) (0-100 μM) shows cytotoxic effects with IC50s of 0.67, 0.90 μM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively.Anticancer agent 50 (0-100 μM) shows antiproliferative effects with IC50s of 3.84, 1.34 μM for sensitive parental (PAR) and resistant (MDR) mouse T-lymphoma cells, respectively.Anticancer agent 50 (0.1, 0.5, 2 μM; 24 h) inhibits cell cycle progression through the reduction of the expression of cyclin D1 and inhibits cell proliferation by inducing p53 expression.Anticancer agent 50 (0.1, 0.5, 2, 10 μM; 72 h) inhibits cell growth by 12% in SH-SY5Y cells.
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