产品
编 号：F753256
分子式：C31H35Cl2N5O3
分子量：596.55
分子式：C31H35Cl2N5O3
分子量：596.55
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CAS No: 2485779-34-6
产品详情
生物活性：
ATX inhibitor 13 (10c) is an orally active and potent ATX inhibitor, with an IC50 of 3.4 nM. ATX inhibitor 13 inhibits proliferation and migration, and induces apoptosis and G2 phase arrest in RAW264.7 cells. ATX inhibitor 13 suppresses tumor cell colony formation.
体内研究：
ATX inhibitor 13 (compound 10c) (C57BL/6J mice, 0-1000 mg/kg, Orally, once) has an acceptable safety profile.Animal Model:C57BL/6J mice (5 groups,4 mice per group)
Dosage:5000, 3200, 2500 and 1000 mg/kg
Administration:Orally, once
Result:Had an acceptable safety profile, showed no obvious safety concerns.
体外研究：
ATX inhibitor 13 (compound 10c) (0-20 μM, 72 h) shows cytotoxicity and anti-proliferative activity against MCF-7, MDA-MB-231, A549, NCI-H1581, H2228, Hep3B, and RAW264.7 cells. ATX inhibitor 13 (0-1 μM, 0-72 h) inhibits migration of RAW264.7 cells in a dose-dependent manner, significantly down-regulates both the colony count and colony single area with the concentration elevation.ATX inhibitor 13 (0-1 μM, 72 h) dose dependently suppresses colony formation of RAW264.7 cells.ATX inhibitor 13 (0-1 μM, 48 h) induces weak apoptosis in a dose-dependent manner in RAW264.7 cells.ATX inhibitor 13 (0-1 μM, 48 h) brings G2 phase arrest of RAW264.7 cells.
ATX inhibitor 13 (10c) is an orally active and potent ATX inhibitor, with an IC50 of 3.4 nM. ATX inhibitor 13 inhibits proliferation and migration, and induces apoptosis and G2 phase arrest in RAW264.7 cells. ATX inhibitor 13 suppresses tumor cell colony formation.
体内研究：
ATX inhibitor 13 (compound 10c) (C57BL/6J mice, 0-1000 mg/kg, Orally, once) has an acceptable safety profile.Animal Model:C57BL/6J mice (5 groups,4 mice per group)
Dosage:5000, 3200, 2500 and 1000 mg/kg
Administration:Orally, once
Result:Had an acceptable safety profile, showed no obvious safety concerns.
体外研究：
ATX inhibitor 13 (compound 10c) (0-20 μM, 72 h) shows cytotoxicity and anti-proliferative activity against MCF-7, MDA-MB-231, A549, NCI-H1581, H2228, Hep3B, and RAW264.7 cells. ATX inhibitor 13 (0-1 μM, 0-72 h) inhibits migration of RAW264.7 cells in a dose-dependent manner, significantly down-regulates both the colony count and colony single area with the concentration elevation.ATX inhibitor 13 (0-1 μM, 72 h) dose dependently suppresses colony formation of RAW264.7 cells.ATX inhibitor 13 (0-1 μM, 48 h) induces weak apoptosis in a dose-dependent manner in RAW264.7 cells.ATX inhibitor 13 (0-1 μM, 48 h) brings G2 phase arrest of RAW264.7 cells.
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