产品
编 号：F753248
分子式：C30H40N2O
分子量：444.65
分子式：C30H40N2O
分子量：444.65
产品类型
规格
价格
是否有货
1mg
询价
询价
结构图
CAS No: 2485005-22-7
产品详情
生物活性：
GPX4-IN-2 is a potent GPX4 inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer.
体内研究：
GPX4-IN-2 (5 mg/kg for mouse, 2 mg/kg for rats; i.v.) 在小鼠和大鼠中显示出良好的药代动力学特征。Animal Model:6-8 weeks, 22-25 g, Male Balb/c mice, 6-8 weeks, 200-250 g, male SD rats
Dosage:5 mg/kg for mouse, 2 mg/kg for rats
Administration:I.v.
Result:Showed a good pharmacokinetics with T1/2 of 3.5 h, Cmax of 5446 ng/mL, AUC of 1635 ng·h/mL, CL of 49 mL/min/kg, Vd of 14.7 L/kg in mice, T1/2 of 3.15 h, Cmax of 3529 ng/mL, AUC of 1082 ng·h/mL, CL of 30 mL/min/kg, Vd of 8.2 L/kg in rats.
体外研究：
GPX4-IN-2 (compound 28) (0.0005-10 mM; 24 h) 显示出抗增殖活性，对于 786-O、SJSA-1、A431 细胞的 IC50 值分别为 0.004、0.016、2.9 μM。
GPX4-IN-2 is a potent GPX4 inhibitor. GPX4 shows antiproliferative activity. GPX4-IN-2 has the potential for the research of cancer.
体内研究：
GPX4-IN-2 (5 mg/kg for mouse, 2 mg/kg for rats; i.v.) 在小鼠和大鼠中显示出良好的药代动力学特征。Animal Model:6-8 weeks, 22-25 g, Male Balb/c mice, 6-8 weeks, 200-250 g, male SD rats
Dosage:5 mg/kg for mouse, 2 mg/kg for rats
Administration:I.v.
Result:Showed a good pharmacokinetics with T1/2 of 3.5 h, Cmax of 5446 ng/mL, AUC of 1635 ng·h/mL, CL of 49 mL/min/kg, Vd of 14.7 L/kg in mice, T1/2 of 3.15 h, Cmax of 3529 ng/mL, AUC of 1082 ng·h/mL, CL of 30 mL/min/kg, Vd of 8.2 L/kg in rats.
体外研究：
GPX4-IN-2 (compound 28) (0.0005-10 mM; 24 h) 显示出抗增殖活性，对于 786-O、SJSA-1、A431 细胞的 IC50 值分别为 0.004、0.016、2.9 μM。
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