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编 号：F753146
分子式：C31H21N5OS
分子量：511.6
分子式：C31H21N5OS
分子量：511.6
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CAS No: 2482310-23-4
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生物活性：
Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research.
体外研究：
Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2MCF-7 and WI-38 cells (normal human cells) with IC50 values of 1.62, 1.46, 2.04 and 117.9 μM, respectively..Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds.
Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research.
体外研究：
Apoptotic agent-3 (compound 15f) (24 hours) has selective anti-proliferative activities against HCT-116, HepG-2MCF-7 and WI-38 cells (normal human cells) with IC50 values of 1.62, 1.46, 2.04 and 117.9 μM, respectively..Apoptotic agent-3 (compound 15f) (24 hours) (1.46 μM; 24 hours; HepG-2 cells) induces cell apoptosis, which increases the levels of active Caspase-3 and BAX by 11.53 folds and 10 folds, respectively, and decreases the level of Bcl-2 by 3.8 folds.
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