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编 号：F753142
分子式：C37H46N2O9
分子量：662.77
分子式：C37H46N2O9
分子量：662.77
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CAS No: 2481404-89-9
产品详情
生物活性：
Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research.
体内研究：
Tubulin polymerization-IN-28 (compound-4) (intraperitoneal injection, every day, 17days) exhibits good anti-cancer activity in HepG2 xenograft-bearing BALB/c mice model in vivo.Animal Model:HepG2 xenograft-bearing BALB/c mice
Dosage:20 mg/kg, 40 mg/kg
Administration:Intraperitoneal injection; every day; 17days
Result:Resulted in 47.49% reduction in tumor growth at a concentration of 20 mg/kg. Resulted in 54.87% reduction in tumor growth at a concentration of 40 mg/kg.
体外研究：
Tubulin polymerization-IN-28 (compound-4) (9-381 nM，48 hours)has a significant inhibitory effect ontumor cells. Tubulin polymerization-IN-28 (compound-4) (10 nM，48 hours) inhibits microtubule assembly with anti-tumor activity. Tubulin polymerization-IN-28 (compound-4) (10 nM，48 hours) causes G2/M phase arrest in cells. Tubulin polymerization-IN-28 (compound-4) (10 nM，24 hours) leads to significant cell apoptosis.
Tubulin polymerization-IN-28 (compound-4) is a microtubule protein polymerization inhibitor with highly selective anticancer activity. Tubulin polymerization-IN-28 can be activated by NQO1 and effectively release combretastatin A-4 to kill tumor cells. Tubulin polymerization-IN-28 can induce cell apoptosis and be used in anti-cancer research.
体内研究：
Tubulin polymerization-IN-28 (compound-4) (intraperitoneal injection, every day, 17days) exhibits good anti-cancer activity in HepG2 xenograft-bearing BALB/c mice model in vivo.Animal Model:HepG2 xenograft-bearing BALB/c mice
Dosage:20 mg/kg, 40 mg/kg
Administration:Intraperitoneal injection; every day; 17days
Result:Resulted in 47.49% reduction in tumor growth at a concentration of 20 mg/kg. Resulted in 54.87% reduction in tumor growth at a concentration of 40 mg/kg.
体外研究：
Tubulin polymerization-IN-28 (compound-4) (9-381 nM，48 hours)has a significant inhibitory effect ontumor cells. Tubulin polymerization-IN-28 (compound-4) (10 nM，48 hours) inhibits microtubule assembly with anti-tumor activity. Tubulin polymerization-IN-28 (compound-4) (10 nM，48 hours) causes G2/M phase arrest in cells. Tubulin polymerization-IN-28 (compound-4) (10 nM，24 hours) leads to significant cell apoptosis.
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