产品
编 号：F753132
分子式：C28H28FN11
分子量：537.59
分子式：C28H28FN11
分子量：537.59
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规格
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结构图
CAS No: 2479961-46-9
产品详情
生物活性：
RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity.
体内研究：
RET-IN-23 (5 mg/kg；口服) 在小鼠中显示出抗肿瘤活性。Animal Model:Balb/c-nu mouse (TT cell subcutaneous xenograft tumor)
Dosage:5 mg/kg
Administration:P.o.
Result:Showed anti-tumor activity with T/C of 17.44%, TGI of 88.82%.
RET-IN-23 (compound 17) is a potent and orally active RET inhibitor with IC50 values of 1.32, 2.50, 6.54, 1.03, 1.47 nM for RET-WT, RET-CCDC6, RET-V804L, RET-V804M, RET-M918T, respectively. RET-IN-23 shows anti-tumor activity.
体内研究：
RET-IN-23 (5 mg/kg；口服) 在小鼠中显示出抗肿瘤活性。Animal Model:Balb/c-nu mouse (TT cell subcutaneous xenograft tumor)
Dosage:5 mg/kg
Administration:P.o.
Result:Showed anti-tumor activity with T/C of 17.44%, TGI of 88.82%.
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