产品
编 号：F753091
分子式：C24H21ClN4
分子量：400.9
分子式：C24H21ClN4
分子量：400.9
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2471981-21-0
产品详情
生物活性：
MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase (MPO). MPO-IN-1 has IC50s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation.
体内研究：
MPO-IN-1 (compound 2) (5 and 90 mg/kg; p.o.; four hours post-Zymosan A administration) significantly reduces MPO activity in a mouse peritonitis model of acute inflammation.Mouse pharmacokinetic parameter of MPO-IN-1.DoseVss(L/kg)T1/2(h)AUCinf(nM•h) p.o.Cmax(nM) p.o.PPB (%)F (%)
1/10 mg/kg i.v./p.o.9.82.6248650299.661
Animal Model:Male C57BL/6J mice (mouse peritonitis model of acute inflammation)
Dosage:5 and 90 mg/kg
Administration:p.o. (four hours post-Zymosan A administration)
Result:Resulted in a ~50% reduction in the MPO activity at 90 mg/kg.
MPO-IN-1 is a potent, orally active, and irreversible indole-containing inhibitor of myeloperoxidase (MPO). MPO-IN-1 has IC50s of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively. MPO-IN-1 inhibits MPO activity in an acute mouse model of inflammation.
体内研究：
MPO-IN-1 (compound 2) (5 and 90 mg/kg; p.o.; four hours post-Zymosan A administration) significantly reduces MPO activity in a mouse peritonitis model of acute inflammation.Mouse pharmacokinetic parameter of MPO-IN-1.DoseVss(L/kg)T1/2(h)AUCinf(nM•h) p.o.Cmax(nM) p.o.PPB (%)F (%)
1/10 mg/kg i.v./p.o.9.82.6248650299.661
Animal Model:Male C57BL/6J mice (mouse peritonitis model of acute inflammation)
Dosage:5 and 90 mg/kg
Administration:p.o. (four hours post-Zymosan A administration)
Result:Resulted in a ~50% reduction in the MPO activity at 90 mg/kg.
产品资料
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