产品
编 号：F753070
分子式：C14H9FN2O3S2
分子量：336.36
分子式：C14H9FN2O3S2
分子量：336.36
产品类型
规格
价格
是否有货
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2470015-35-9
产品详情
生物活性：
Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage.
体外研究：
Anticancer agent 43 (compound 3a) shows selectivity toward human tumor cells (SI50=28.94).Anticancer agent 43 (45 μM, 24 h) induces apoptosis via caspase 3, PARP1 and Bax dependent pathways in HepG2 cells.Anticancer agent 43 (45 μM, 24 h) shows no effect on the transition of G1/S phases in HepG2 cells.Anticancer agent 43 (0.7, 45, 55 μM) induces DNA damage in HCT116 cells (Tail DNA=16.1%, OTM=3.7), MCF-7 cells, HepG2 cells (Tail DNA=26.2%, OTM=13.2), Balb/c 3T3 cells (Tail DNA = 8.4%, OTM = 3.5).
Anticancer Agent 43 is a potent anticancer agent. Anticancer Agent 43 induces apoptosis by caspase 3, PARP1, and Bax dependent mechanisms. Anticancer Agent 43 induces DNA damage.
体外研究：
Anticancer agent 43 (compound 3a) shows selectivity toward human tumor cells (SI50=28.94).Anticancer agent 43 (45 μM, 24 h) induces apoptosis via caspase 3, PARP1 and Bax dependent pathways in HepG2 cells.Anticancer agent 43 (45 μM, 24 h) shows no effect on the transition of G1/S phases in HepG2 cells.Anticancer agent 43 (0.7, 45, 55 μM) induces DNA damage in HCT116 cells (Tail DNA=16.1%, OTM=3.7), MCF-7 cells, HepG2 cells (Tail DNA=26.2%, OTM=13.2), Balb/c 3T3 cells (Tail DNA = 8.4%, OTM = 3.5).
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