产品
编 号:F753001
分子式:C19H14N2O4S
分子量:366.39
产品类型
结构图
CAS No: 2461795-23-1
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产品详情
生物活性:
Anticancer agent 47 (compound 4j) is a potent anticancer agent. Anticancer agent 47 shows antiproliferative activities. Anticancer agent 47 induces apoptosis and cell cycle arrest at G0/G1 phase. Anticancer agent 47 shows shows antitumor activities in vivo.
体内研究:
Anticancer agent 47 (20 mg/kg; i.v.; once every 2 days for 19 days) shows antitumor activities.Animal Model:BALB/c nude mice (HepG2 xenografts)
Dosage:20 mg/kg
Administration:I.v.; once every 2 days for 19 days
Result:Effectively inhibited tumor growth with the 58.7% tumor inhibition rate.
体外研究:
Anticancer agent 47 (compound 4j) shows antiproliferative activities with IC50s of 1.6, 0.72, 7.07 μM for HepG2, A549, H596 cells, respectively.Anticancer agent 47 (0.8, 1.6, 3.2 μM; 24 h) induces apoptosis and cell cycle arrest at G0/G1 phase.Anticancer agent 47 (5 μM; 5h) significantly increases ROS production.