产品
编 号：F752980
分子式：C228H388N86O64
分子量：5358.06
分子式：C228H388N86O64
分子量：5358.06
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
10mg
询价
询价
结构图
CAS No: 2460055-10-9
产品详情
生物活性：
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells.
体内研究：
FOXO4-DRI (5 mg/kg; i.p.; every other day for three administrations) 缓解自然衰老小鼠睾丸激素分泌不足，改善睾丸微环境。Animal Model:Naturally aged male C57BL/6 mice (20-24 months old)
Dosage:5 mg/kg
Administration:Intraperitoneal injection, every other day for three administrations
Result:Increased serum testosterone levels. Increased levels of both 3β-HSD and CYP11A1. Decreased interstitial SA-β-gal activity and lowered levels of senescence-associated proteins p53, p21, and p16. Decreased the levels of IL-1β, IL-6 and TGF-β.
体外研究：
FOXO4-DRI (25 mM; 3 days) 引起活性 p53 的核排斥，诱导衰老 TM3 Leydig 细胞凋亡。FOXO4-DRI (25 μM; 5 days) 显著降低 PDL9 细胞的衰老水平。
FOXO4-DRI is a cell-permeable peptide antagonist that blocks the interaction of FOXO4 and p53. FOXO4-DRI is a senolytic peptide that induces apoptosis of senescent cells.
体内研究：
FOXO4-DRI (5 mg/kg; i.p.; every other day for three administrations) 缓解自然衰老小鼠睾丸激素分泌不足，改善睾丸微环境。Animal Model:Naturally aged male C57BL/6 mice (20-24 months old)
Dosage:5 mg/kg
Administration:Intraperitoneal injection, every other day for three administrations
Result:Increased serum testosterone levels. Increased levels of both 3β-HSD and CYP11A1. Decreased interstitial SA-β-gal activity and lowered levels of senescence-associated proteins p53, p21, and p16. Decreased the levels of IL-1β, IL-6 and TGF-β.
体外研究：
FOXO4-DRI (25 mM; 3 days) 引起活性 p53 的核排斥，诱导衰老 TM3 Leydig 细胞凋亡。FOXO4-DRI (25 μM; 5 days) 显著降低 PDL9 细胞的衰老水平。
产品资料
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