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编 号:F752975
分子式:C16H17N5O2
分子量:311.34
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生物活性:
COX-2/PI3K-IN-2 (compound 5f) is a potent PI3K inhibitor with IC50 value of 2.78 nM. COX-2/PI3K-IN-2 is a selective COX-2 inhibitor with Ki value of 3.02 nM. COX-2/PI3K-IN-2 shows anti-inflammatory and anti-cancer properties.

体外研究:
COX-2/PI3K-IN-2 (compound 5f) (50-500 μg/mL, 72 hours) exerts potent antitumor activities against Breast cancer (MCF-7) cells.COX-2/PI3K-IN-2 (compound 5f) (10-150 μg/mL) has antioxidant properties with H2O2 scavenging activity equivalent to ascorbic acid and higher lysozyme inhibition (IC50=3.25 nM).
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