产品
编 号：F752974
分子式：C22H15N5O2S
分子量：413.45
分子式：C22H15N5O2S
分子量：413.45
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CAS No: 2459932-81-9
产品详情
生物活性：
EGFR-IN-49 is a potent and selective EGFR inhibitor with IC50s of 65.0 nM and 13.6 nM for EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-49 induces late apoptosis in a dose-dependent manner.
体外研究：
EGFR-IN-49 (compound 13a) (1, 10 μM) shows inhibition activity for H1975 cells with an IC50 of 699.2 nM.EGFR-IN-49 (1 μM) shows an strong inhibitory activity to EGFRT790M, EGFRT790M/L858R, EGFRWT with IC50s of 65.0, 13.6, >1000 nM, respectively.EGFR-IN-49 (0.2, 4, 8 μM; 48 h) induces cell apoptosis in a dose-dependent manner in A431 cells.
EGFR-IN-49 is a potent and selective EGFR inhibitor with IC50s of 65.0 nM and 13.6 nM for EGFRT790M and EGFRT790M/L858R, respectively. EGFR-IN-49 induces late apoptosis in a dose-dependent manner.
体外研究：
EGFR-IN-49 (compound 13a) (1, 10 μM) shows inhibition activity for H1975 cells with an IC50 of 699.2 nM.EGFR-IN-49 (1 μM) shows an strong inhibitory activity to EGFRT790M, EGFRT790M/L858R, EGFRWT with IC50s of 65.0, 13.6, >1000 nM, respectively.EGFR-IN-49 (0.2, 4, 8 μM; 48 h) induces cell apoptosis in a dose-dependent manner in A431 cells.
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