产品
编 号:F752936
分子式:C47H48BClF2N6O5
分子量:861.18
产品类型
结构图
CAS No: 2456476-47-2
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产品详情
生物活性:
BBR-BODIPY is a fluorescent probe that allows screening its interaction with the targeted cells. BBR-BODIPY induces apoptosis and changes the expression of apoptosis-related proteins.
体外研究:
BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) has anti-proliferative activity.BBR-BODIPY (2-16 μM; 5-60 mins; MCF7 cells) could be quickly taken up into MCF7 cells in 5 mins and the fluorescence intensity exhibits a time-dependent manner.BBR-BODIPY (1-32 μM; 24 hours; MCF7 and MDA-MB-231 cells) accumulates in mitochondria and overlaps with Mito tracker red to display yellow fluorescence with a Pearsons co-localization coefficient of 0.72.BBR-BODIPY (8 μM, 12 hours) induces apoptosis in MCF7 cells through a mitochondrial pathway.