产品
编 号：F752904
分子式：C17H11N3O4S2
分子量：385.42
分子式：C17H11N3O4S2
分子量：385.42
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
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10mg
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25mg
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50mg
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结构图
CAS No: 2454113-83-6
产品详情
生物活性：
GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC50s of 11.4 μM and 6.8 μM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity.
体内研究：
GLUT4-IN-2 (50 mg/kg; i.p. on day 1–5, 8–12, 15–18) shows antitumor activity in CEM xenograft model.Animal Model:8–10 weeks, SCID mice (CEM xenograft tumor)
Dosage:50 mg/kg
Administration:I.p.; administered on day 1-5, 8-12, 15-18
Result:Showed potent antitumor activity in vivo.
体外研究：
GLUT4-IN-2 (compound F18) induces cell apoptosis and ell cycle arrest at G0/G1phase in CME cells.GLUT4-IN-2 (10 μM; 6 h) decreases the expression of mTOR and CDK2, but increases the expression of GRP78, and cleaved caspase 3 proteins .
GLUT4-IN-2 is a potent and selective GLUT4 inhibitor with IC50s of 11.4 μM and 6.8 μM for GLUT1 and GLUT4, respectively. GLUT4-IN-2 induces cell apoptosis and cell cycle arrest at G0/G1phase. GLUT4-IN-2 shows potent antitumor activity.
体内研究：
GLUT4-IN-2 (50 mg/kg; i.p. on day 1–5, 8–12, 15–18) shows antitumor activity in CEM xenograft model.Animal Model:8–10 weeks, SCID mice (CEM xenograft tumor)
Dosage:50 mg/kg
Administration:I.p.; administered on day 1-5, 8-12, 15-18
Result:Showed potent antitumor activity in vivo.
体外研究：
GLUT4-IN-2 (compound F18) induces cell apoptosis and ell cycle arrest at G0/G1phase in CME cells.GLUT4-IN-2 (10 μM; 6 h) decreases the expression of mTOR and CDK2, but increases the expression of GRP78, and cleaved caspase 3 proteins .
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