产品
编 号：F752903
分子式：C20H15NO7
分子量：381.34
分子式：C20H15NO7
分子量：381.34
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CAS No: 2454024-18-9
产品详情
生物活性：
HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 μM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase.
体外研究：
HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C50s of 9.56, 13.32, 10.46, 6.91 μM for MCF-7, HCT-116, HepG2, Hela cells, respectively.HDAC-IN-42 (1, 5, 10 μM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells.HDAC-IN-42 (1, 5, 10 μM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase.
HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 μM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase.
体外研究：
HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C50s of 9.56, 13.32, 10.46, 6.91 μM for MCF-7, HCT-116, HepG2, Hela cells, respectively.HDAC-IN-42 (1, 5, 10 μM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells.HDAC-IN-42 (1, 5, 10 μM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase.
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