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编 号：F752895
分子式：C18H13ClF3N5O
分子量：407.78
分子式：C18H13ClF3N5O
分子量：407.78
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CAS No: 2453228-45-8
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生物活性：
Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity.
体外研究：
Anticancer agent 71 (Compound 4b) (0.1-50 μM, 24 hours; SW480 and PC3 cells) increases the cytotoxicity and exerts potent antitumor activities against SW480 and PC3 cells.Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours; SW480 cells) induces a significant G2/M phase arrest.Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours) induces apoptosis in SW480 cells by upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression.
Anticancer agent 71 (Compound 4b) is a potent anticancer agent and induces apoptosis. Anticancer agent 71 arrests cell cycle at G2/M phase and induces apoptosis through upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression levels. Anticancer agent 71 shows antiproliferative activity.
体外研究：
Anticancer agent 71 (Compound 4b) (0.1-50 μM, 24 hours; SW480 and PC3 cells) increases the cytotoxicity and exerts potent antitumor activities against SW480 and PC3 cells.Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours; SW480 cells) induces a significant G2/M phase arrest.Anticancer agent 71 (Compound 4b) (11.08 μM, 24 hours) induces apoptosis in SW480 cells by upregulating Bax, Ikb-α and cleaved PARP and downregulating Bcl-2 expression.
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