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编 号:F752894
分子式:C36H35N3O4
分子量:573.68
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生物活性:
Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS.

体内研究:
Nampt-IN-8 (Compound 10d) (0-20 mg/kg) substantially inhibits the growth of A549/taxol xenograft tumors in vivo with no significant toxicity.

体外研究:
Nampt-IN-8 (Compound 10d) shows antiproliferative activity with an IC50 of 1.15 μM.
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