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编 号:F752759
分子式:C34H35FN4O7
分子量:630.66
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生物活性:
c-Met/HDAC-IN-3 (Compound 15f) is a dual c-Met and HDAC inhibitor with IC50 values of 12.50 nM and 26.97 nM against c-Met and HDAC1, respectively. c-Met/HDAC-IN-3 induces apoptosis and cause cell cycle arrest in G2/M phase.

体外研究:
c-Met/HDAC-IN-3 (Compound 15f) (0-20 μM, 72 h) shows antiproliferative activities against HCT-116, MCF-7 and A549 cells.c-Met/HDAC-IN-3 (0-5 μM, 48 h) induces apoptosis and arrests cell cycle at G2/M phase.
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