产品
编 号：F752682
分子式：C22H27N3O3S
分子量：413.53
分子式：C22H27N3O3S
分子量：413.53
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CAS No: 2428478-22-0
产品详情
生物活性：
NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis.
体内研究：
在小鼠中的药代动力学分析RouteDose (mg/kg)T1/2 (h)Tmax (h)Cmax (ng/mL)AUC0-inf (ng·h/mL)MRT0-inf (h)Vz (mL/kg)Cl (mL/h/kg)F (%)
i.v.54.010.08322567130240/5.3022638.8
p.o.103.500.667338672219554.79//85.21
NLRP3-IN-20 (compound 11) is an orally available inhibitor of the NLRP3 inflammasome with an IC50 of 25 nM for IL-1β secretion. NLRP3-IN-20 has excellent pharmacokinetic properties and demonstrated significant efficacy in models of non-alcoholic steatohepatitis, fatal septic shock, and colitis.
体内研究：
在小鼠中的药代动力学分析RouteDose (mg/kg)T1/2 (h)Tmax (h)Cmax (ng/mL)AUC0-inf (ng·h/mL)MRT0-inf (h)Vz (mL/kg)Cl (mL/h/kg)F (%)
i.v.54.010.08322567130240/5.3022638.8
p.o.103.500.667338672219554.79//85.21
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