产品
编 号：F752670
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规格
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是否有货
1mg
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询价
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CAS No: 2428381-55-7
产品详情
生物活性：
Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity.
体内研究：
Ligufalimab (0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model) 抑制小鼠肿瘤生长。Animal Model:SCID/Beige mice (Raji xenograft model, MDA-MB-231 xenograft model)
Dosage:0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model
Administration:I.v.
Result:Inhibited tumor growth with the tumor inhibition rate of 88.56%, 63.78% at 1, 0.1 mg/kg.
体外研究：
Ligufalimab 结合人 CD47 抗原，EC50 值为 0.078 nM，KD 值为 0.152 nM。Ligufalimab (0-3000 nM) 不诱导红细胞血凝。Ligufalimab (0.1、1、10 μg/mL) 以剂量依赖性方式诱导 Raji、Jurkat 和 Ramos 细胞的吞噬作用。
Ligufalimab (AK 117) is a humanized IgG4 anti-CD47 monoclonal antibody. Ligufalimab does not induce RBC hemagglutination, and induces phagocytosis. Ligufalimab shows anti-tumor activity.
体内研究：
Ligufalimab (0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model) 抑制小鼠肿瘤生长。Animal Model:SCID/Beige mice (Raji xenograft model, MDA-MB-231 xenograft model)
Dosage:0.1, 1 mg/kg for Raji xenograft, 0.2 mg/kg for MDA-MB-231 xenograft model
Administration:I.v.
Result:Inhibited tumor growth with the tumor inhibition rate of 88.56%, 63.78% at 1, 0.1 mg/kg.
体外研究：
Ligufalimab 结合人 CD47 抗原，EC50 值为 0.078 nM，KD 值为 0.152 nM。Ligufalimab (0-3000 nM) 不诱导红细胞血凝。Ligufalimab (0.1、1、10 μg/mL) 以剂量依赖性方式诱导 Raji、Jurkat 和 Ramos 细胞的吞噬作用。
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