产品
编 号：F752659
分子式：C18H18N8O2
分子量：378.39
分子式：C18H18N8O2
分子量：378.39
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CAS No: 2426705-19-1
产品详情
生物活性：
ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities.
体外研究：
ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis.ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase.
ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities.
体外研究：
ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis.ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase.
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