产品
编 号:F752657
分子式:C107H150N34O32S2
分子量:2488.67
产品类型
结构图
CAS No: 2426685-25-6
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产品详情
生物活性:
TPP-1 is a potent inhibitor of the?PD-1/PD-L1 interaction. TPP-1 binds specifically to PD-L1 with a high affinity (KD=95 nM). TPP-1 inhibits human tumor growth in vivo via reactivating T-cell function.
体内研究:
TPP-1 (subcutaneous injection; 4 mg/kg; every other day eight times; 32 days) inhibits tumor growth (compared with SPP-1 and control). The growth rate in TPP-1-treated mice is 56%. And when administered in the absence of T cells (control group), TPP-1 has no effect on the growth of the H460-luc tumors.Animal Model:5 to 6-week-old female Balb/c nude mice? injected with H460 cells transfected with the plvx-puro/luciferase lentiviral vector
Dosage:4 mg/kg
Administration:Subcutaneous injection; 4 mg/kg; every other day eight times; 32days
Result:Inhibited the tumor growth in a tumor xenograft model via reactivating T-cell function.?
体外研究:
TPP-1 binds to PD-L1 with high affinity and blocks PD-1/PD-L1 interaction.?The?KD?value of PD-L1 with TPP-1 peptide is about 95 nmol/L (around five times less than that with PD-1), The binding site of TPP-1 to PD-L1 is close to the interactive site of PD-1 and PD-L1.TPP-1 (4 μM) reactivates T-cell functions, it induces IFNγ release significantly higher than control and SPP-1, and the TPP-1 group shows similar outcomes for cell proliferation.