产品
编 号：F752655
分子式：C20H21NO6
分子量：371.38
分子式：C20H21NO6
分子量：371.38
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CAS No: 2426665-56-5
产品详情
生物活性：
Tubulin polymerization-IN-13 (Compound 4f) is a tubulin polymerization inhibitor (IC50=0.37 μM). Tubulin polymerization-IN-13 shows anti-proliferative activity against cancer cells, induces apoptosis and potential antivascular activity.
体内研究：
Tubulin polymerization-IN-13 (intraperitoneal injection; 15 or 5 mg/kg; once every other day; 4 times) reduces tumor growth in a dose-dependent manner in an orthotopic murine tumor model.Animal Model:Seven-week-old C57BL/6 female mice orthotopically injected into the mammary fat pad with E0771 mammary carcinoma cells
Dosage:15 or 5 mg/kg
Administration:Intraperitoneal injection; 15 or 5 mg/kg; once every other day; 4 times
Result:Reduced tumor mass by 45.7% and 16.9% at 15 and 5 mg/kg, respectively.Showed no sign of toxicity and no decreasement in animal body weight.
体外研究：
Tubulin polymerization-IN-13 (0.005-2.8 nM) treatment inhibits tumor cell proliferation.Tubulin polymerization-IN-13 (8.7-10 μM) is non-toxic in non-tumor cells.Tubulin polymerization-IN-13 (1-50 nM; 24 h) treatment induces cell cycle arrest in G2/M.Tubulin polymerization-IN-13 (10 nM; 24 and 48 h) treatment induces cell apoptosis.Tubulin polymerization-IN-13 (10-100 nM; 24 h) treatment induces alteration of the microtubule network.
Tubulin polymerization-IN-13 (Compound 4f) is a tubulin polymerization inhibitor (IC50=0.37 μM). Tubulin polymerization-IN-13 shows anti-proliferative activity against cancer cells, induces apoptosis and potential antivascular activity.
体内研究：
Tubulin polymerization-IN-13 (intraperitoneal injection; 15 or 5 mg/kg; once every other day; 4 times) reduces tumor growth in a dose-dependent manner in an orthotopic murine tumor model.Animal Model:Seven-week-old C57BL/6 female mice orthotopically injected into the mammary fat pad with E0771 mammary carcinoma cells
Dosage:15 or 5 mg/kg
Administration:Intraperitoneal injection; 15 or 5 mg/kg; once every other day; 4 times
Result:Reduced tumor mass by 45.7% and 16.9% at 15 and 5 mg/kg, respectively.Showed no sign of toxicity and no decreasement in animal body weight.
体外研究：
Tubulin polymerization-IN-13 (0.005-2.8 nM) treatment inhibits tumor cell proliferation.Tubulin polymerization-IN-13 (8.7-10 μM) is non-toxic in non-tumor cells.Tubulin polymerization-IN-13 (1-50 nM; 24 h) treatment induces cell cycle arrest in G2/M.Tubulin polymerization-IN-13 (10 nM; 24 and 48 h) treatment induces cell apoptosis.Tubulin polymerization-IN-13 (10-100 nM; 24 h) treatment induces alteration of the microtubule network.
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