产品
编 号：F752611
分子式：C27H31FN4O2
分子量：462.56
分子式：C27H31FN4O2
分子量：462.56
产品类型
规格
价格
是否有货
10mM*1mL in DMSO
询价
询价
5mg
询价
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10mg
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询价
25mg
询价
询价
50mg
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询价
结构图
CAS No: 2421141-51-5
产品详情
生物活性：
M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer.
体内研究：
1.19Pharmacokinetic Properties of M4K2234 in Mice . MicePO 3 mg/kg
Cmax(ng/mL)1650
AUCinf(ng·h/mL)4630
t1/2(h)2.61
体外研究：
M4K2234 (0-5 μM) shows inhibitory effects against WT and DIPG-linked mutant forms of ALK2 with IC50s of 5, 3, 6 and 6 nM for WT, G328V, R206H and R258G, respectively.
M4K2234 (compound 26b) is an ALK2 inhibitor. M4K2234 inhibits ALK2 and ALK5 with IC50s of 5 and 2144 nM, respectively. M4K2234 can be used as a chemical probe for ALK1 and ALK2 protein kinases. M4K2234 can be used for the research of cancer.
体内研究：
1.19Pharmacokinetic Properties of M4K2234 in Mice . MicePO 3 mg/kg
Cmax(ng/mL)1650
AUCinf(ng·h/mL)4630
t1/2(h)2.61
体外研究：
M4K2234 (0-5 μM) shows inhibitory effects against WT and DIPG-linked mutant forms of ALK2 with IC50s of 5, 3, 6 and 6 nM for WT, G328V, R206H and R258G, respectively.
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