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编 号:F752595
分子式:C42H67N11O4
分子量:790.05
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生物活性:
ADG-2e is a potent antibacterial agent with MICs of 16, 4, 2, and 2 μg/mL for E. coli [KCTC 1682], P. aeruginosa [KCTC 1637], B.subtilis [KCTC 3068], and S. aureus [KCTC 1621], respectively. ADG-2e shows anti-metastatic activity against breast cancer cells.

体外研究:
ADG-2e (1-64 μg/mL, 22 hours) exhibits twice the antibacterial activity compared to other antibiotics in methicillin-resistant S. aureus (MRSA) or multidrug-resistant P. aeruginosa (MDRPA) .ADG-2e (0-60 μg/mL, 2 hours) shows only slight hemolysis with increasing concentration.ADG-2e (0-100 μM, 24 hours) does not inhibit the proliferation of MDA-MB-231 cells but has a role in the migration of cancer cells by inserting into the surface of them and affecting cell motility.ADG-2e (0-40 μM, 6 hours) causes actin reorganization to promote its multiple lamellar structures formation.
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