产品
编 号：F752540
分子式：C34H53N15O6
分子量：767.88
分子式：C34H53N15O6
分子量：767.88
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CAS No: 2417283-44-2
产品详情
生物活性：
MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity.
体内研究：
Animal Model:Rats
Dosage:2.5 mg/kg
Administration:Intravenous injection; once
Result:The pharmacokinetic parameters of MI-1851 (compound 8) ParameterMI-1851 (compound 8)
t1/21.6 h
total body clearance273 mL/(h?kg)
Cmax3156 ng/mL
体外研究：
MI-1851 (0-100 μM, 2h, 24 h) does not affect PHH cells viability, and extracellular hydrogen peroxide production even at 100 μM but reduces CYP3A4 isoenzyme activity in PHH cells in a dose-dependent manner.MI-1851 (10-50 μM, 72 h) strongly inhibits the spread of SARS-CoV-2 and its proliferation in Calu-3 cells even at a low dose of 10 μM, which reduces the virus titer by 30 to 190-fold. MI-1851 (compound 8) (0.5-16 μM, 48 h) inhibits DENV-2 and WNV replication with the EC50 values of 1.50 μM and 1.46 μM, respectively in huh-7 cells.
MI-1851 is a potent furin inhibitor. MI-1851 prevents the proteolytic processing of the S protein of SARS-CoV-2 by endogenous flavoprotease in HEK293 cells. MI-185 has antiviral activity.
体内研究：
Animal Model:Rats
Dosage:2.5 mg/kg
Administration:Intravenous injection; once
Result:The pharmacokinetic parameters of MI-1851 (compound 8) ParameterMI-1851 (compound 8)
t1/21.6 h
total body clearance273 mL/(h?kg)
Cmax3156 ng/mL
体外研究：
MI-1851 (0-100 μM, 2h, 24 h) does not affect PHH cells viability, and extracellular hydrogen peroxide production even at 100 μM but reduces CYP3A4 isoenzyme activity in PHH cells in a dose-dependent manner.MI-1851 (10-50 μM, 72 h) strongly inhibits the spread of SARS-CoV-2 and its proliferation in Calu-3 cells even at a low dose of 10 μM, which reduces the virus titer by 30 to 190-fold. MI-1851 (compound 8) (0.5-16 μM, 48 h) inhibits DENV-2 and WNV replication with the EC50 values of 1.50 μM and 1.46 μM, respectively in huh-7 cells.
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