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编 号:F752506
分子式:C29H18BrN3O2
分子量:520.38
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生物活性:
Anti-MRSA agent 3 (compound 18) has highly inhibitory activity against Methicillin-resistant Staphylococcus aureus (MRSA) with MIC of 0.098 μg/ml, and low cytotoxicity in normal cells. Anti-MRSA agent 3 has relatively strong ability to destroy bacterial cell wall and membrane, high binding affinity to bacterial genomic DNA.

体内研究:
Anti-MRSA agent 3 has potent efficacy at a dose of 10 mg/kg (20% survival) in a mouse peritonitis model.
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