产品
编 号：F752420
分子式：C18H14N4O3S2
分子量：398.46
分子式：C18H14N4O3S2
分子量：398.46
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CAS No: 2414598-85-7
产品详情
生物活性：
hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 μM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) .
体外研究：
hCAIX-IN-12 (compound OX27) shows antiproliferative effect with IC50s of 6.0 μM for HCT-116 cells.hCAIX-IN-12 decreases the expression of CAIX in HCT-116 cells and inhibits the expression of CAIX more pronouncedly in hypoxic conditions.hCAIX-IN-12 (0-50 μM; 0-48 h) inhibits the colony formation in a dose-dependent manner and 7 inhibits the migration of HCT-116 cells.hCAIX-IN-12 (6.0 μM; 48 h) induces apoptosis in HCT-116 cells.hCAIX-IN-12 (6.0 μM; 24,48 h) increases in the levels of ROS in HCT-116 cells.hCAIX-IN-12 causes depletion of HCT-116 cells in the G0/G1 (P2 65.21%) phase with an increase in the accumulation of cells in G2/M (P4 18.95%) phase.hCAIX-IN-12 has high binding affinity for CAIX and substantial affinity for HSA.
hCAIX-IN-12 is a potent hCAIX inhibitor with IC50 values of 0.74, 10.78 μM for CAIX and CAII, respectively. hCAIX-IN-12 shows antiproliferative effect and induces apoptosis. hCAIX-IN-12 increases ROS production. hCAIX-IN-12 has the potential for the research of colorectal cancer (CRC) .
体外研究：
hCAIX-IN-12 (compound OX27) shows antiproliferative effect with IC50s of 6.0 μM for HCT-116 cells.hCAIX-IN-12 decreases the expression of CAIX in HCT-116 cells and inhibits the expression of CAIX more pronouncedly in hypoxic conditions.hCAIX-IN-12 (0-50 μM; 0-48 h) inhibits the colony formation in a dose-dependent manner and 7 inhibits the migration of HCT-116 cells.hCAIX-IN-12 (6.0 μM; 48 h) induces apoptosis in HCT-116 cells.hCAIX-IN-12 (6.0 μM; 24,48 h) increases in the levels of ROS in HCT-116 cells.hCAIX-IN-12 causes depletion of HCT-116 cells in the G0/G1 (P2 65.21%) phase with an increase in the accumulation of cells in G2/M (P4 18.95%) phase.hCAIX-IN-12 has high binding affinity for CAIX and substantial affinity for HSA.
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