产品
编 号：F752387
分子式：C26H27ClN4O3
分子量：478.97
分子式：C26H27ClN4O3
分子量：478.97
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规格
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CAS No: 2414053-06-6
产品详情
生物活性：
COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research.
体外研究：
COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC50 values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively.COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%).COX-2-IN-23 (compound A10) exhibits Cu2+ chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity.
COX-2-IN-23 (compound A10) is a potent both AChE and HDAC inhibitor with IC50 values of 0.12 and 0.23 nM. COX-2-IN-23 exhibits antioxidant activity and metal chelating properties. COX-2-IN-23 can be used in alzheimer's disease research.
体外研究：
COX-2-IN-23 (compound A10) is a potent dual AChE and HDAC inhibitor with IC50 values of 0.12, 361.52, 0.23 and 9050 nM for AChE, BChE, HDAC and ABTS, respectively.COX-2-IN-23 (compound A10) has antioxidant activity and exhibits inhibitory activity on Aβ1-42 self-aggregation (34.2%) as well as disaggregation activity on pre-formed Aβ fibrils (41.24%).COX-2-IN-23 (compound A10) exhibits Cu2+ chelating properties, promoting the amyloid protein aggregation leads to aggravating the neurotoxicity.
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