产品
编 号：F752355
分子式：C24H29NO4
分子量：395.49
分子式：C24H29NO4
分子量：395.49
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CAS No: 2413656-04-7
产品详情
生物活性：
AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro.
体内研究：
AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice.Animal Model:Kunming mice at body weight of 18–22 g (male and female in half)
Dosage:1.0, 5.0 and 25.0 mg/kg
Administration:Intragastric administration, once a day for 7 consecutive days
Result:Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.
体外研究：
AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE.
AChE-IN-21 (Compound I-8) is a potent, selective and orally active AChE inhibitor with an IC50 of 2.66 nM. AChE-IN-21 displays excellent BBB permeability in vitro.
体内研究：
AChE-IN-21 (Compound I-8) (0-25 mg/kg; i.g.; once a day for 7 consecutive days) significantly reverses scopolamine-induced memory deficit in mice.Animal Model:Kunming mice at body weight of 18–22 g (male and female in half)
Dosage:1.0, 5.0 and 25.0 mg/kg
Administration:Intragastric administration, once a day for 7 consecutive days
Result:Obviously blocked scopolamine (2 mg/kg, i.p.)-induced memory deficit.
体外研究：
AChE-IN-21 (Compound I-8) binds to both the catalytic active site and peripheral anionic site of AChE.
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