产品
编 号：F752352
分子式：C20H14BrN3O2
分子量：408.25
分子式：C20H14BrN3O2
分子量：408.25
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规格
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CAS No: 2413603-15-1
产品详情
生物活性：
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
体外研究：
HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 0.58 and 8 μM, respectively
HDAC6-IN-5 (compound 11b) is a potent and BBB-penetrated HDAC6 inhibitor, with an IC50 of 0.025 μM. HDAC6-IN-5 exhibits strong inhibitory activity against Aβ1-42 self-aggregation and AChE, with IC50 values of 3.0 and 0.72 μM. HDAC6-IN-5 can enhance neurite outgrowth without significant neurotoxicity.
体外研究：
HDAC6-IN-5 (compound 11b) induces histone H3 and α-tubulin acetylation in a dose-dependent manner, with EC50 values of 0.58 and 8 μM, respectively
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