产品
编 号:F752263
分子式:C18H18F3N5O2S
分子量:425.43
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1mg
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5mg
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生物活性:
NBD-14270, a pyridine analogue, is a potent HIV-1 entry antagonist with an IC50?of 180 nM against 50 HIV-1 Env-pseudotyped viruses. NBD-14270 binds to HIV-1 gp120 and shows potent antiviral activity. NBD-14270 shows low cytotoxicity (CC50>100 μM).

体外研究:
NBD-14270 has anti-HIV-1 activity (IC50=0.16 μM ) and Cytotoxicity (CC50=109.3 μM) in single-cycle (TZM-bl Cells) assay. NBD-14270 does not induce toxicity in the U87-CD4-CXCR4 cell line at the doses used for this assay.
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