产品
编 号：F752138
分子式：C37H43FN8O4S
分子量：714.85
分子式：C37H43FN8O4S
分子量：714.85
产品类型
规格
价格
是否有货
1mg
询价
询价
5mg
询价
询价
结构图
CAS No: 2408872-84-2
产品详情
生物活性：
Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.
体内研究：
Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice.Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma.Animal Model:Colo205 tumor-bearing mice
Dosage:50 mg/kg, twice a week
Administration:Oral gavage
Result:Inhibited tumor growth by 93.63%
Animal Model:Rats, colo205 tumor-bearing mice
Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration:Oral administration
Result:Pharmacokinetic profile of Cimpuciclib (example 63). dose Cmax (ng/mL)Tmax (h) AUC0-24 (ng/mL?h) t1/2 (h)
5 mg/kg (rats)559.7654142.4
50 mg/kg (mice)7960113678214.8
体外研究：
Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells.
Cimpuciclib tosylate is a selective CDK4 inhibitor (IC50: 0.49 nM) that has anti-tumor activity.
体内研究：
Cimpuciclib (example 63, 50 mg/kg, oral gavage, twice a week) tosylate inhibits tumor growth in colo205 tumor-bearing mice.Cimpuciclib (5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice, oral administration) tosylate shows slow metabolic rate and maintains high concentration in the plasma.Animal Model:Colo205 tumor-bearing mice
Dosage:50 mg/kg, twice a week
Administration:Oral gavage
Result:Inhibited tumor growth by 93.63%
Animal Model:Rats, colo205 tumor-bearing mice
Dosage:5 mg/kg for rats, 50 mg/kg for colo205 tumor-bearing mice.
Administration:Oral administration
Result:Pharmacokinetic profile of Cimpuciclib (example 63). dose Cmax (ng/mL)Tmax (h) AUC0-24 (ng/mL?h) t1/2 (h)
5 mg/kg (rats)559.7654142.4
50 mg/kg (mice)7960113678214.8
体外研究：
Cimpuciclib (example 63, 141.2 nM, 6 days) tosylate inhibits proliferation of colo205 cells.
产品资料
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